Objective: To prepare tissue engineered bone with bone marrow mesenchymal stem cells and force growth factor using calcium phosphate cement / fibrin glue as composite carrier, and to observe the effect of this implant on repairing osteoporotic bone defect in rats. Methods: The rat model of osteoporotic bone defect was made, and the composite bone scaffold constructed in vitro (group C: CPC/FG/MGF/BMSCs) was implanted into the area of osteoporotic bone defect, and compared with group A (implanted CPC/FG material) and group B (implanted CPC/FG/BMSCs). The specimens were taken at 4 and 8 weeks after operation, and the repair of bone defect was observed by radiology, histological staining and immunohistochemistry. Results: The progress of bone repair in group C was faster than that in group An and B at 4 and 8 weeks after operation, and the immunohistochemical analysis showed that the positive expression of ALP in group C was higher than that in group B and group An at 4 weeks after operation. At 8 weeks after operation, the positive expression of ALP in group C and group B was significantly higher than that in group A (P < 0.05). At the same time, there was no significant difference between group C and group B (P > 0.05). Conclusion: The preliminary evaluation of the in vivo repair experiment of radius defect in osteoporotic rats shows that the calcium phosphate cement / fibrin glue composite scaffold of load growth factor and bone marrow mesenchymal stem cells may have a good ability to repair osteoporotic bone defect, and its mechanism and efficacy should be further studied.