[Objective] To investigate the clinical effectiveness of homodigital radial neurocutaneous flap innervated by terminal branches of the lateral antebrachial cutaneous nerve and the surperficial branch of radial nerve for repair of soft tissue defect of thumb fingertip or palm. [Methods] From May 2018 to June 2020, 20 cases of soft tissue defects of thumb fingertip or palm hospitalized were reviewed retrospectively. The defects were repaired by homodigital radial neurocutaneous flap innervated by terminal branches of the lateral antebrachial cutaneous nerve and the surperficial branch of radial nerve. And the donor-site defect of the flap was closed directly. [Results] All flaps survived uneventfully. The mean follow-up time was 12 months (range from 9 to 16 months). The appearance of the injured thumbs were good and the texture, color and thickness of the flap was similar to the surrounding tissue. There was only linear scar at the donor site of the radial thumb. At the final follow-up, the evaluation of range of motion of the injured thumb was graded as excellent in 15 cases and good in five cases. The values of static 2-point discrimination of the flaps ranged from 4 to 8 mm (mean, 6.2 mm). The appearance evaluation of the injured limb were strongly satisfied (score 5) in 16 patients and satisfied (score 4) in the remaining four patients. [Conclusion] Compared with neurocutaneous flap innervated by single cutaneous nerve, this flap innervated by terminal branches of the lateral antebrachial cutaneous nerve and the surperficial branch of radial nerve has better sense and is an ideal method for treating soft tissue defect of thumb fingertip or palm.