Spinal Cord Injury (SCI) is a serious and irreversible central nervous system injury disease. There is no effective treatment method at present. Electro-spinning is a common method for preparing nano-scale fiber membrane materials. The method, which has the advantages of high porosity, adjustable pore size, high surface-to-volume ratio, and corresponding to the shape of extracellular matrix, is widely used in the field of biomedicine.This article reviews the characteristics of electrospinning and the preclinical research progress of electrospinning for spinal cord injury, in order to explore a new idea for the treatment of spinal cord injury.