Abstract Objective To retrospectively analyze the clinical effect of platelet rich plasma(PRP) combined with percutaneous endoscopic lumbar discectomy (PELD).Methods From January 2019 to December 2019, 73 patients with lumbar disc herniation(LDH) were selected, including 41 males and 32 females; the average annual age was 48.52 ± 10.36 years; there were 14 cases of L3-4, 37 cases of L4-5 and 22 cases of L5-S1; the average course of disease was 10.26 ± 4.05 months; protrusion type: 51 cases of protrusion type and 22 cases of free type. According to the operation plan, 36 cases were divided into the observation group (PRP+PELD) and 37 cases were divided into the control group (PELD). Perioperative complications, pain visual analogue score(VAS), Oswestry functional impairment index(ODI), intervertebral height index (IHI) and Pfirrmann grade were observed.Results ① All the operations were completed successfully, and there were no cases of infection during the perioperative period. Dural tear: there were 2 cases in the observation group, of which 1 case had cerebrospinal fluid leakage; There were 3 cases in the control group. Nerve root contusion: 3 cases in the observation group and 2 cases in the control group were treated with neuronutrition and acupuncture, recovered after 2 months of follow-up. Incision hematoma: 1 case in the control group, through local drainage. ②The two groups were followed up for 12-18 months, with an average of 15.37 ± 1.92 months. There was no recurrence or reoperation during follow-up. One month after operation, VAS in the observation group was significantly better than that in the control group (P < 0.05). At the last follow-up, the ODI score of the observation group was better than that of the control group (P < 0.001). ③ At the last follow-up, there was no significant difference in IHI between the observation group and that before operation (P > 0.05); The IHI of L4-5 and L5-S1 in the observation group was significantly higher than that in the control group (P < 0.05). ④ At the last follow-up, the proportion of Pfirrmann grade I-II signals in the observation group was 75.00% (27 / 36), which was better than the control group 51.35% (19 / 37). There was significant difference between the two groups (x2 = 4.378, P = 0.036).Conclusion PRP combined with PELD in the treatment of LDH could reduce postoperative inflammatory reaction, improve the microenvironment of intervertebral disc, and is conducive to the repair of fibrous ring and the stability of the stability of vertebral body.