Abstract: [Objective] To investigate the clinical effect of percutaneous vertebroplasty for the treatment of vertebral blowout fracture in the elderly without nerve injury. [Methods] Forty-eight elderly patients with vertebral burst fracture without nerve injury were enrolled in this study, and all were treated with PVP. VAS score and ODI score were recorded before surgery, on the 1st postoperative day and at the last follow-up. The height of the anterior, middle and posterior edges of the injured vertebrae relative to the vertebral body and the kyphosis Cobb Angle were measured on X-ray lateral radiographs, and the complications such as bone cement leakage were observed. [Results] All 48 patients were successfully operated. Follow-up showed that VAS score, ODI score, relative vertebral height and Cobb Angle of all patients were significantly improved on day 1 after surgery compared with those before surgery, with statistical significance (P<0.05). VAS score and ODI score at the last follow-up were further lower than that at the first postoperative day (P<0.05), while relative vertebral height and Cobb Angle were not significantly lost (P>0.05). There were 8 patients with bone cement leakage, and no serious complications such as bone cement embolism and neurological symptoms caused by bone cement leakage occurred after surgery. [Conclusion] PVP has a reliable effect on the treatment of senile vertebral blowout fracture without nerve injury.