Abstract:Abstract: Nontraumatic osteonecrosis of the femoral head (NONFH) is a common clinical orthopaedic disease.?Blood circulation disorder is one of the main causes of NONFH, so improving blood circulation is of great significance for the prevention and treatment of NONFH in the early and middle stages.?Multiple signal pathways can prevent and treat NONFH by improving blood circulation. PI3K / Akt, as an important signal pathway, can improve blood circulation by regulating upstream and downstream factors, so as to prevent and treat NONFH.?This paper mainly discusses the role of PI3K / Akt signaling pathway in affecting NONFH through many factors leading to blood circulation, such as lipid metabolism disorder and vascular regeneration.?It can regulate and improve blood circulation by affecting upstream and downstream factors such as vascular endothelial growth factor, P2Y12 receptor and nitric oxide synthase, so as to provide a new reference and basis for the prevention and treatment of NONFH.