[Objective] To explore the clinical efficacy of unilateral biportal endoscopy for far-migrated lumbar intervertebral disc herniation. [Methods] A retrospective analysis was conducted on the data of 19 patients who underwent unilateral biportal endoscopy for far-migrated lumbar intervertebral disc herniation in our department from April 2020 to December 2020. Of them, 10 males and 9 females aged 17~60 years with an average of (36.95±12.22) years. The segments involved L4/5 in 13 cases and L5/S1 in 6 cases. The legs involved right in 12 cases, left in 6 cases and both in 1 case. The documents of perioperative period, follow-up and radiographic results were summarized. [Results] All patients had operation completed successfully without serious complications. The operation time was (75.37±13.62) min, blood loss was (61.84±20.45) ml, while the times of fluoroscopy were (2.84±0.83). The patient""s VAS score of lower back and leg continued to decrease significantly after the operation (P<0.05). By 30 days after the operation, the patient""s pain basically disappeared. The modified ODI score decreased significantly, while the JOA score increased significantly over time (P<0.05). Modified Macnab criterion evaluated at the last follow-up indicated an efficacy of 16 excellent cases, 2 good and 1 fair, the satisfactory (excellent and good) result was 94.74%. At the latest follow-up, MRI showed far-migrated lumbar intervertebral discs were successfully removed without recrudescence. [Conclusion] Unilateral biportal endoscopy is an effective method for far-migrated lumbar intervertebral disc herniation, with low X-ray exposure, small surgical trauma and reliable clinical efficacy. Meanwhile, the migrated discs were removed completely.