[Objective] to introduce a new surgical technique and preliminary clinical results of percutaneous lumbar fusion Methods] from December 2017 to February 2019, 23 patients with lumbar spondylolysis spondylolisthesis underwent the above surgical treatment. Percutaneous pedicle puncture under C-arm fluoroscopy and placement of guide wire, 6 ~ 9cm beside the posterior midline as the needle entry point, sliding off segment intervertebral space puncture, expansion and shaping of intervertebral foramen under the guidance of guide wire, placement of working cannula, enlargement and decompression of lateral recess and intervertebral foramen under endoscopy; Then, under the guidance of guide wire, self-made instruments were used to open the intervertebral space step by step. Then, pedicle screws and connecting rods were inserted along the guide wire for lifting and reduction of spondylolisthesis vertebral body. Put reamer and curette into self-made working channel to clean intervertebral space and endplate. After cleaning under microscope, implant autologous bone (or allogeneic bone) and intervertebral fusion cage. Adjust the fastening nail bar system to complete the fixation Results] all the operations were successfully completed without serious complications. At the last follow-up, VAS score, ODI score, intervertebral space height and spondylolisthesis distance of low back pain and leg pain were significantly improved compared with those before operation (P Conclusion] the new percutaneous lumbar fusion technique for the treatment of lumbar spondylolysis spondylolisthesis is feasible, in line with the current minimally invasive development direction of spinal surgery, and is a safe and effective minimally invasive operation.