[Objective] To compare the effects of oral and intravenous tranexamic acid (TXA) in reducing bleeding from unicompartmental knee arthroplasty (UKA). [Method] From June 2020 to June 2021, sixty-one cases of UKA patients admitted to our hospital, including 30 cases of oral TXA (oral group) and 31 cases of intravenous TXA (intravenous group)。The perioperative period, follow-up and auxiliary examination results were compared between the two groups. [Result] The operations were successfully completed in all patients, and no serious complications occurred during the operations. There was no significant difference in the basic conditions of the two groups of patients before operation (P>0.05). During the hospitalization period, the oral group had 2 cases of lower extremity intermuscular venous thrombosis, 1 case of gastrointestinal discomfort; 3 cases of lower extremity intermuscular venous thrombosis of the venous group, 1 case of incision swelling, and 1 case of blood transfusion. There was no statistically significant difference in operation time, total length of incision, intraoperative blood loss, postoperative drainage, total blood loss, apparent blood loss, hidden blood loss, blood transfusion rate, walking time, incidence of symptomatic thrombosis, incision healing, in hospitalization time and hospitalization expenses. There was no significant difference in Hb and Hct between the two groups before operation and on the 1st and 3rd day after operation (P>0.05). [Conclusion] The effects of oral and intravenous tranexamic acid on perioperative blood loss, blood transfusion rate, and incidence of venous thrombosis in patients undergoing unicondylar arthroplasty are similar.