The Second Affiliated Hospital of Shandong First Medical University
目的：高血压和Ⅱ型糖尿病（type 2 diabetes mellitus,T2DM）已被证明和骨密度（bone mineral density, BMD）之间存在相关关系，但对于中老年男性T2DM 患者血压水平与BMD的关系鲜有研究。这项研究旨在研究中老年男性T2DM 患者不同血压水平对BMD的影响，并分析其他可能影响该部分人群BMD的影响因素。方法：我们纳入了99名中老年男性T2DM 患者，收集有关医学史、药物史和生活习惯，并对受试者进行了一般资料测量、实验室检验和BMD的测定。结果：不同血压受试者在一般资料、生活习惯及实验室检验结果中差异无统计学意义。分析显示，中老年男性T2DM合并中度高血压患者的BMD较正常血压受试者有更低的BMD。我们对血压水平进行分组评价，发现BMD和血压水平并不是显示线性关系，而是在不同的血压梯度之间表现为不同的相关关系。吸烟会增加腰椎骨质减少的风险，血脂与BMD存在一定相关性，可能是骨质疏松发生的影响因素。结论：对于中老年男性T2DM患者，血压控制在较低水平更有利于骨质健康。
Objective: Hypertension and type 2 diabetes mellitus (T2DM) have been shown to have a correlation with bone mineral density (BMD), but the relationship between blood pressure and BMD in middle-aged and elderly men with T2DM There is little research. This study aims to study the effects of different blood pressure levels on BMD in middle-aged and elderly men with T2DM, and to analyze other factors that may affect BMD in this part of the population. Methods: We enrolled 99 middle-aged and elderly men with T2DM, collected relevant medical history, drug history, and lifestyle habits, and performed general data measurement, laboratory tests, and BMD determinations on the subjects. Results: There was no statistically significant difference in general data, living habits and laboratory test results among subjects with different blood pressure. Analysis shows that middle-aged and elderly men with T2DM and moderately hypertensive BMD have lower bone density than normal blood pressure subjects. We grouped and evaluated blood pressure levels and found that BMD and blood pressure levels did not show a linear relationship, but showed different correlations between different blood pressure gradients. Smoking increases the risk of lumbar osteopenia. There is a certain correlation between blood lipids and bone density, which may be an influencing factor for osteoporosis. Conclusion: For middle-aged and elderly men with T2DM, controlling blood pressure at a lower level is more conducive to bone health.