Abstract:Abstract: [Objective] To discuss the clinical efficacy of disease vertebral nailing and diseased intervertebral fixation in the treatment of single-segment lumbar brucellosis spondylitis. [Methods] A retrospective analysis of 21 patients with single-segment lumbar brucellosis spondylitis from November 2016 to December 2019, including 15 males and 6 females, aged 42 to 64 years, were used one-stage posterior lumbar lesion removal, disease vertebral nailing and diseased intervertebral fixation. The bone graft fusion rate and complication rate after surgery were recorded. At the same time, compare the visual analogue scale (VAS) the japanese orthopaedic association scores (JOA), the oswestry disability index (ODI), erythrocyte sedimentation rate (ESR) and C-Reactive protein (CRP) before and after the operation to evaluate clinical efficacy. [Results] Two weeks after surgery and one year after surgery, VAS, JOA, ODI, ESR, and CRP were significantly different from those before surgery (P all<0.001). Moreover, VAS, JOA, ODI, ESR, and CRP were statistically different at 1 year after operation compared with 2 weeks after operation (P all<0.001). At the last follow-up, all patients obtained bony fusion and no recurrence. [Conclusions] It is safe and feasible to perform one-stage posterior lumbar lesion removal, disease vertebral nailing and diseased intervertebral fixation.