Objective To explore the effects of locking proximal humerus plate (LPHP) and hollow screw fixation on fracture healing and shoulder joint function in patients with shoulder dislocation and greater tuberosity fracture of the humerus. Methods A total of 76 patients with shoulder dislocation and greater tuberosity fracture of the humerus who were admitted to our hospital from January 2016 to March 2019 were selected as the research objects. According to the operation method, it was divided into a steel plate group (n=40) and a screw group (n=36) with a hollow screw fixation treatment. The perioperative blood loss, operation time, and incision length were recorded in the two groups, and the affected limb’s abduction, external rotation, and flexion range of motion (ROM), shoulder joint score, excellent and good rate, fracture healing time, and fracture healing time were recorded during regular follow-up after the operation. Fracture reduction quality. Results The blood loss, operation time, and incision length in the screw group were lower than those in the steel plate group, and the differences were statistically significant (P<0.05). Compared with preoperatively, the ROM of shoulder joint abduction, external rotation, and flexion increased in the two groups at the last follow-up, and the screw group was higher than the steel plate group, the difference was statistically significant (P<0.05). The score and excellent rate of shoulder joint in the screw group were higher than those in the plate group, and the difference was statistically significant (P<0.05). At the last follow-up, the fractures of the two groups were healed, and there was no significant difference in healing time (P>0.05). The excellent reduction rate of the screw group (61.11%) was higher than that of the plate group (52.50%), and the difference was statistically significant (P<0.05).