Abstract:[Objective] To compare the outcomes of two dural sealing repair methods for prevention of cerebrospinal fluid leakage. [Methods] A retrospective study was conducted on 72 patients with intraspinal subdural tumors from January 2015 to December 2018. Of them, 32 patients underwent gelatin sponge covering after tumor resection and dural suture, and the remaining 40 patients underwent fat and gelatin sponge covering after tumor resection and dural suture. The clinical results were compared between the two groups. [Results] There were no significant differences in operative duration, intraoperative blood loss, length of dural incision and incidence of surgical site infection between the two groups (P>0.05). The postoperative drainage volume, drainage time, postoperative hospital stay and incidence of cerebrospinal fluid leakage in the fat and gelatin sponge group were all lower than those in the gelatin sponge group (P<0.05). The mean follow-up time was (28.24±4.63) months. The VAS scores in both groups decreased significantly over time (P<0.05). At the same time point, there was no statistically significant difference in VAS scores between the two groups (P>0.05). There was no statistical significance in the efficacy of modified Macnab between the two groups (P>0.05). [Conclusion] For patients with intraspinal subdural tumors, covering with fat and gelatin sponge after removing tumor and suturing dura was superior to covering with gelatin sponge.