Objective:To investigate the clinical association between symptomatic benign prostatic hyperplasia(BPH) and periprosthetic joint infection after primary total hip arthroplasty(THA).Methods:A total of 133 male patients who underwent total hip arthroplasty in our hospital from January 2011 to December 2018 were selected and divided into two groups according to whether there was Periprosthetic joint infection (PJI) after the operation. PJI group 10 cases, 123 cases in the non-PJI group. At the same time collect the patient’s age, BMI, operation time, blood transfusion volume, anesthesia method, whether it is combined with sBPH, diabetes history, preoperative albumin level, indwelling drainage tube, drainage tube placement time and drainage volume around the prosthesis after artificial hip replacement Univariate analysis of infection. Multivariate logistic regression analysis was performed with the dichotomous variable of whether PJI occurred as the dependent variable, and other factors as independent variables. Results:All selected cases were followed up with an average follow-up time of 5.80±1.77 years. The results of univariate analysis showed that combined sBPH, diabetes history, BMI, preoperative albumin level, indwelling drainage tube, drainage tube placement time, drainage volume, and urinary tract infection The infection around the prosthesis after hip replacement was related (P<0.05), and the age, operation time, blood transfusion and the method of anesthesia were not related to the infection around the prosthesis after hip replacement (P>0.05). The logistic regression results of PJI showed that patients with sBPH had an increased risk of prosthetic infection after THA (OR=3.267, 95%CI: 1.83-6.56).Conclusion: Patients with symptomatic benign prostatic hyperplasia (sBPH) are at higher risk for periprosthetic joint infections after primary total hip replacement.In addition, symptomatic benign prostatic hyperplasia is one of the independent risk factors for periprosthetic joint infection after primary total hip replacement,which are clinically correlated.