【Abstract】 Objective: To investigate the biomechanical characteristics of a new type of pedicle screws of lumbar spine designed by ourselves in human osteoporosis lumbar spine. Methods: 4 lumbar spine specimens (L1-5) with osteoporosis were studied. The specimens were divided into observation group (group A) and control group (group B) by Interval grouping method. The observation group A1- A8 vertebrae were fixed with 2 new type pedicle screws, and horizontal titanium rod was installed to connect the screws on both sides; B1-B8 in control group was fixed with 2 common pedicle screws; A9 and B9 were double vertebrae, four screws were connected with two longitudinal titanium rods, and A9 were also connected with two horizontal titanium rods. The screw pulling out test was performed on the above specimens, the maximum pulling output of each specimen was recorded, and the damage of the nail channel was observed by CT. Results: In biomechanical test, the maximum pulling out force (1173.24 ± 244.57 n) measured in the observation group was higher than that of the control group (705.23 ± 264.09 n), and the difference was statistically significant (t = 3.678, P = 0.002). After the pulling out test, the damage of screw channels were different in the two groups: 4 cases of had unilateral lateral pedicle fracture and 2 vertebral fractures in observation group; no pedicle or vertebral fracture were found in the control group; when the screws were pulled out in the observation group, the angle between the screw and the transverse titanium rod did not change; when the screws were pulled out in the control group, the abduction angle decreased and the nail channel loosened. Conclusion: Compared with the common pedicle screw, the new type of posterior fixation screw has better stability in osteoporosis and can reduce the probability of screw loosening.