[Objective] To explore the clinical effect of the anterior pelvic wall locking plate in the treatment of acetabular fractures involving the quadrilateral plate. [Method] A retrospective analysis of 32 patients with acetabular fractures involving the quadrilateral plate treated with anterior pelvic wall plates in our hospital from January 2017 to December 2020, including 22 males and 10 females; age 23-82 years, average 52.7 years old . The fracture classification was based on Letournel-Judet classification: 6 cases of anterior wall with posterior semi-transverse fractures, 7 cases of transverse fractures, 12 cases of double-column fractures and 7 cases of T-shaped fractures. All patients were exposed through the lateral rectus approach. According to the specific location of the fracture line, the anterior pelvic wall plate combined with the reconstruction plate was selected for fixation. The quality of fracture reduction was assessed by Matta imaging standard, and hip joint function was assessed according to the modified Merled’Aubigné-Postel scoring standard. [Results] The patients in this study were followed up for 12-41 months, with an average of 25.7 months. At the last follow-up, Matta imaging evaluation showed that 23 cases (71.9%, 23/32) were anatomically reduced, 7 cases were satisfied (21.9%, 7/32), and 2 cases were dissatisfied (6.2%, 2/32), and the satisfaction rate was 93.8% (30/32); according to the modified Merled'Aubigné-Postel scoring standard, the hip function was excellent in 22 cases, good in 6 cases, fair in 3 cases, and poor in 1 case. The excellent and good rate was 87.5% (28/32). There was 2 case of deep vein thrombosis of lower limbs after operation. [Conclusion] The translateral rectus approach combined with the anterior pelvic wall locking plate to fix the acetabular fracture involving the quadrilateral plate can achieve satisfactory clinical results.