Abstract:OBJECTIVE This study aimed to evaluate the biomechanical effects of lateral lumbar interbody fusion constructs with novel anterior pedicle screw fixation using finite element analysis. METHODS A three-dimensional finite element model of the lumbar vertebrae (L3~S1) was constructed and validated. After the validation of successful modeling, 5 finite element models were constructed, including anterior lumbar pedicle screw and plate (4 crews ALPSP), anterior lumbar pedicle screw and rod (2 crews ALPSR), lateral vertebrae screw (LVS), unilateral pedicle screw (UPS) and bilateral pedicle screw (BPS). Stress peak of superior endplates and cage, Von Mises stress program was noted as well. RESULTS The ROM of the finite element model was consistent with the published data. Compared to the intact group, ALPSP provided the optimal control of ROM at extension left and right lateral bending. BPS provided the optimal control of ROM at flexion, left and right axial rotation In extension left and right lateral bending, the stress peak of superior endplates in ALPSP is minimum and BPS took second place. In the flexion, left and right axial rotation, the stress peak of superior endplates in BPS is minimum and ALPSP took second place. The stress of the cage had the relevant tendency. CONCLUSIONS ALPSP provides favorable biomechanical stability, which is similar to the BPS and superior to LVS and UPS. And it decreases the risk of subsidence of the cage.