]Objective：To explore the effect of the distal femur anatomical locking plate internal fixation for the treatment of distal femoral fractures. Methods: 100 patients with distal femoral fractures treated by surgery in our hospital were selected for clinical research. Among them, 50 patients were treated with open anatomical locking plate internal fixation (plate group), and the other 50 patients were treated with retrograde intramedullary nail internal fixation (intramedullary Nail group); compare the two groups' surgical procedures, fracture healing indicators, postoperative knee function recovery, surgical complications and other indicators. Results: The operation time and total blood loss in the steel plate group were greater than those of the intramedullary nail group, and the difference was statistically significant (P<0.05); the comparison of the knee joint exercise time and fracture healing time between the steel plate group and the intramedullary nail group All were not statistically significant (P>0.05); the range of motion of the knee joint was measured at 3 months, 5 months, and 6 months after surgery. The steel plate group was lower than the intramedullary nail group, and the difference was statistically significant (P< 0.05); 6 months after the operation, the rate of good knee function in the plate group was 72.00% lower than that of the intramedullary nail group, which was 90.00%, the difference was statistically significant (P<0.05); postoperative complications occurred in the plate group In 6 cases (12.00%), 2 cases (4.00%) in the intramedullary nail group had related complications after operation. The difference between the two groups was not significant (P>0.05). Conclusion: The treatment of distal femur anatomical locking plate internal fixation has a reliable surgical effect, but compared with retrograde intramedullary nail internal fixation, its operation time is longer, the amount of bleeding is larger, and the postoperative joint function recovery is slightly worse.