Abstract: Objective To explore the effect of computer-aided design and computer-aided manufacture (CAD/CAM) orthoses on adolescent patients with idiopathic scoliosis. Methods From January 2018 to December 2019, 62 adolescent idiopathic scoliosis patients with Cobb Angle 25-50° (main curve) in Sichuan Orthopaedic Hospital were treated with othoses. They were randomly divided into plaster group and CAM group, with 31 cases in each group. After 1 and 2 years of treatment, height and imaging data of the two groups were collected for statistical analysis, and the SF-36 health survey was completed for quality of life assessment at the last follow-up. Results The last follow-up was compared with before treatment, the height of patients in both groups increased significantly (P<0.05), and the Cobb Angle decreased significantly (P<0.01), the deviation distance of apical vertebral translation (AVT) decreased significantly (P<0.05), The deviation distance between C7 plumb line and central sacral vertical line (C7-CSVL) was decreased in both groups, but the difference was not statistically significant (P>0.05). There were no significant differences in height, Cobb Angle, C7-CSVL and AVT between the plaster group and CAM group at 1-year follow-up and the last follow-up (P>0.05), but the SF-36 scale score in CAM group was significantly higher than that in the plaster group (P<0.01). Conclusion CAD/CAM orthosis is effective in the treatment of adolescent idiopathic scoliosis, and the method of shaping and design is convenient and fast, which is worthy of clinical promotion.