Objective: To investigate the curative effect and long-term prognosis of early avascular necrosis of the femoral head (ANFH) treated by rmast minimally invasive decompression, autogenous bone compression and bone grafting combined with zoledronic acid and platelet rich plasma (PRP) injection. Methods: One hundred and thirty patients with early femoral head necrosis in our hospital from June 2019 to December 2019 were randomly divided into two groups: the study group (n=65) was treated with minimally invasive decompression through rmast channel under the guidance of Tianji orthopedic surgical robot, the autogenous iliac bone was taken for compression and bone graft, and zoledronic acid and autogenous platelet rich plasma were injected into the bone graft end after operation; the control group (n=65) was only treated with operation. The postoperative pain, hip function recovery and long-term prognosis were observed. Results: ①Complications: there was no significant difference in the incidence of complications between the study group and the control group (χ2=0.151，P=0.698) . ②Harris score: from preoperative to 3,6 months after operation, the Harris score of the study group and the control group continued to increase, and the difference was statistically significant (F=171.950,81.571, P<0.05); 3,6 months after operation, the Harris score of the study group was higher than that of the control group (t=4.627,7.767, P<0.05). ③VAS score: from preoperative to 3 and 6 months after operation, the VAS score of hip joint pain in the two groups decreased continuously, and the difference was statistically significant (F=445.924, 445.924, P<0.05). ④Long term prognosis: the survival rate of femoral head in the study group was higher than that in the control group (χ2=5.598, P=0.014). Conclusion: RMAST minimally invasive channel decompression, autologous bone grafting combined with zoledronic acid, PRP injection in the treatment of early femoral head necrosis has a definite effect, can improve the long-term prognosis of patients.