[Objective] To investigate the clinical outcomes of intramedullary nail enhanced by plate for femoral subtrochanteric fractures, comparing with closed reduction intramedullary nail. [Methods] A retrospective study was conducted on 40 patients who underwent surgical treatment for femoral subtrochanteric fractures from January 2015 to January 2020. Including 16 patients underwent intramedullary nail enhanced by plate (enhanced by plate group), and 24 patients underwent closed reduction intramedullary nail (intramedullary group). [Results] All patients were followed-up for 12-60 months. In the control group, there was 1 case of bone nonunion, and the fracture healed 5 months after the second operation with plate fixation. There was no significant difference in intraoperative blood loss, duration of hospital stay and time to walk between the two groups. enhanced by plate group had longer incision, shorter operation time, less number of fluoroscopy and less time to full load comparing with intramedullary group. In terms of VAS score, the pain in the two groups decreased over time, and there was no statistical difference between the two groups at 1 week, 6 months and the final visit after surgery. However, the enhanced by plate group was lower than the control group at 3 months after surgery. In terms of Harris score and ROM, the score of both groups increased and the function recovered over time. There was no statistical difference between the two groups 6 months after surgery and the final visit. However, at 3 months after surgery, the enhanced by plate group was higher than the intramedullary group with statistical difference. Quality of fracture reduction was better in in the enhanced by plate group and the fracture healing in the enhanced by plate group was faster than that in the intramedullary group.[Conclusion] The treatment of subtrochanteric fracture patients with intramedullary nail enhanced by plate has fast functional recovery, short fracture healing time and good clinical efficacy, which is worthy of promotion. Key words: plate, intramedullary nail, femoral subtrochanteric fracture, clinical outcomes.