Abstract: [Objective] To analyze the clinical efficacy and safety of radial collateral artery lobulated perforator flap in the repair of hand irregular wounds. [Methods] 106 patients with traumatic skin injury of hands in our hospital from February 2017 to March 2020 were retrospectively analyzed. The patients in the lobulated group were treated with radial collateral artery lobulated perforator flap (56 cases), and the patients in the conventional group were treated with conventional flap repair (50 cases). The observation indexes included perioperative conditions, follow-up indexes and imaging evaluation. [Results] The operation time, intraoperative blood loss and hospital stay in the lobulated group were significantly lower than those in the conventional group (P < 0.05). At the last follow-up, the tissue growth score of the lobulated group was significantly better than that of the conventional group, while the pain score was significantly lower than that of the conventional group (P < 0.05). The incidence of bleeding, infection, liquefaction, flap necrosis and other adverse reactions in the lobulated group was significantly lower than that in the conventional group (P < 0.05). [Conclusion]In the patients with irregular wounds of the hand, the radial collateral artery lobulated perforator flap has a satisfactory effect in restoring the tissue growth ability and improving the recovery effect; it can also effectively reduce the perioperative indicators and avoid the impact of surgical trauma on rehabilitation.