布病脊柱炎巨噬细胞极化及相关炎症因子变化的研究进展
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首都医科大学附属北京地坛医院

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Research progress of macrophage polarization and related inflammatory factors in brucellosis spondylitis
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1.Beijing Ditan Hospital;2.Department of Orthopedic Surgery, Beijing Ditan Hospital, Capital Medical University, Beijing

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    摘要:

    布鲁氏菌病患者常合并骨与关节损害并发症,最常见的就是布鲁氏菌性脊柱炎(简称布病脊柱炎)。当布鲁氏菌侵犯脊柱后常常出现椎间盘炎症和椎体的骨质破坏,有时还可能产生椎管内、椎旁组织炎症坏死和/或脓肿,进一步导致脊髓、神经根受压、脊柱不稳的症状,造成四肢功能障碍甚至瘫痪, 严重影响患者的生活质量。一旦发生布鲁氏菌感染,布鲁氏菌主要被人体内巨噬细胞吞噬,并寄生在宿主的巨噬细胞内,引起巨噬细胞极化释放相关炎症因子;如肿瘤坏死因子-α (tumor necrosis factor-α, TNF-α)、白介素因子家族(interleukins, IL) 趋化因子家族 (chemokines)。研究表明这些炎症因子在布病脊柱炎的炎症和骨质破坏中起到了重要作用。同时,不同极化类型的巨噬细胞转化可调控炎症和骨破坏的发生及发展方向,本文将对巨噬细胞极化相关炎症因子在布病脊柱炎发病机制中可能的作用机制作一综述。

    Abstract:

    Brucellosis patients often have complications of bone and joint damage, the most common of which is Brucella spondylitis (brucellosis spondylitis for short). When Brucella invades the spine, intervertebral disc inflammation and bone destruction of vertebral body often occur in the spine, and sometimes inflammatory necrotic tissues and/or abscesses in the spinal canal and paravertebral body may be produced, which further leads to the symptoms of spinal cord and nerve root compression and spinal instability, resulting in limb dysfunction or even paralysis, which seriously affects the quality of life of patients. Once Brucella infection occurs, Brucella is mainly swallowed by human macrophages and parasitized in host macrophages, causing macrophages to release related inflammatory factors in polarization. Such -α (tumor necrosis factor-α, TNF-α-α), interleukin family (IL) and chemokine family (CC chemokines). The research shows that these inflammatory factors play an important role in inflammation and bone destruction of brucellosis spondylitis. At the same time, the transformation of macrophages with different polarization types can regulate the occurrence and development direction of inflammation and bone destruction. This article will review the possible mechanism of macrophage polarization-related inflammatory factors in the pathogenesis of brucellosis spondylitis.

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  • 收稿日期:2021-03-03
  • 最后修改日期:2022-06-18
  • 录用日期:2022-10-25
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