Abstract: [Objective] To investigate the correlation between cortical bone thickness values and CT values of cancellous bone and fragility fractures of the hip in the proximal femur of clinically high-risk individuals for osteoporosis (men aged 50 years and older and postmenopausal women). [Method]A retrospective study of the thickness values of cortical bone at different parts of the proximal femur and CT values of cancellous bone in 146 subjects, including 73 cases in the femoral neck fracture group and 73 cases in the non-fracture group.The CT values of the cancellous bone in the coronal position of the proximal femur, the femoral neck and the intertrochanter were measured, and the thickness of the cortical bone between the femoral neck and the trochanter was measured.[Results]①In the femoral neck and intertrochanteric area, the CT value of the fracture group was lower than that of the non-fracture group (p<0.05); while at the femoral head, the difference in CT value was not statistically significant. ②The thickness of the medial and lateral cortical bone between the femoral neck and intertrochanteric in the fracture group was thinner than that in the non-fracture group (p<0.05).[Conclusion]The cortical bone thickness of femoral neck and intertrochanteric bone and CT value of cancellous bone are closely related to femoral neck fracture. The cortical bone thickness of lateral femoral neck and intertrochanteric bone is an important factor related to hip fracture.