Objective To explore the curative effect of anti-movement nail in the treatment of a type of tibial hypertrophic nonunion, which occurs after the failure of interlocking intramedullary nailing to treat tibial shaft fractures. Methods A retrospective analysis of 34 patients admitted to our hospital from January 2014 to December 2019. All of these patients were treated with interlocking intramedullary nail surgery due to tibial shaft fractures. All patients failed the operation and developed hypertrophic bone defects. There were 15 males and 19 females; aged 21-58 years old, with an average of (39.55±10.85) years old; all were closed fractures. AO classification: 12 cases of type A, 17 cases of type B, and 5 cases of type C.After the diagnosis of nonunion in 34 patients, anti-movement nail were inserted into the loose side of the nonunion.Observe the fracture healing of the patient after applying the anti-movement naill through X-ray examination.Results All 34 patients were followed up completely. The follow-up time ranged from 13 to 36 months, with an average of (20.21±6.26) months.Among 34 cases, 31 cases achieved bone healing, the healing time was 3-9 months, with an average of (5.71±1.40) months.Three patients did not heal. They were cured after replacing them with a larger diameter intramedullary nail and bone grafting.The fracture healing rate of the patients in this group was 91.12% after applying the anti-movement nail. Conclusion for the treatment of non infective hypertrophic nonunion after interlocking intramedullary nailing for tibial shaft fracture, the use of anti-movement nail can enhance the stability of the fracture end and promote bone healing.