[Objective] To compare the clinical effect of static staple and plate fixation for metatarsal neck fracture. [Methods] Retrospective analysis was performed on the data of 36 patients with 2nd to 5th metatarsal neck fracture between January 2017 and March 2019 in the Department of Orthopedics, Tianjin Fifth Central Hospital. 18 patients were treated with static staple and 18 with plate. Static staple group: 12 male cases, 6 female cases, the average age (35.26?4.75). Plate groups: 11 male cases, 7 female cases, average age (34.15?5.21). The American Association of Foot and Ankle Surgery (AOFAS) score and the active flexion and extension range of metatarsophalangeal joint were measured to compare the clinical efficacy of the two groups. Fracture healing time and operation time were recorded, and postoperative complications were counted. [Results] All patients were followed up from13 to 18 months, the average (15.71?2.21) months. Fractures healed in all patients, and there were no statistically significant differences between the two groups in fracture healing time, operation time and AOFAS score (P>0.05). At the last follow-up, there were statistically significant differences between the two groups in the active dorsal extension and flexion range of metatarsophalangeal joints (P<0.05). 1 case of open fracture in the Static staple group had local skin necrosis, and 3 cases had metatarsalgia after weight-bearing walking. 2 cases in the Plate group had metatarsalgia, and 3 cases had joint adhesion. [Conclusions] The treatment of the 2nd ~ 5th metatarsal neck fracture by static staple is minimally invasive and firmly fixed. It can effectively reduce the complications of joint adhesion, and is beneficial to the fracture healing and joint function recovery.