Abstract: Objective To retrospectively analyze the short-term efficacy of talisnave-wedge joint fusionand talonavicular joint fusion in the treatment of Muller-Weiss disease.MethodsThe data of 17 patients (25 feet) with Muller-Weiss disease admitted from March 2015 to August 2019 were retrospectively analyzed, of which 16 feet were treated with talisnave-wedge joint fusion and 9 feet were treated with talonavicular joint fusion. Postoperative midfoot function American Orthopaedic Foot and Ankle Society（AOFAS） and related imaging parameters, including Tomeno-Meary Angle, medial longitudinal arch angle（MLAA）and calcaneal pitch angle（CPA）were observed in 2 groups.Results The operative time and the number of autogenous iliac bone grafts in talonavicular wedge fusion group were significantly higher than talonavicular fusion group (P<0.01).All the 17 patients were followed up for an average of 12.37±3.24 months. All patients had bony healing with a mean healing time of 10.37±5.16 weeks.At the last follow-up, the AOFAS score and VAS score in the talisnave-wedge fusion group were better than that in the talisnave-wedge fusion group (P<0.05).There were no statistically significant differences in TMA, MLAA and CPA between the two groups before operation, but postoperative TMA, MLAA and CPA were significantly better than preoperation (P<0.001). TMA, MLAA and CPA in talisnave-wedge group were better than those in the talonavicular joint fusion group (P<0.05).Conclusion Talisnave-wedge fusion is better than talonavicular joint fusion in treating the Muller Weiss disease Ⅲ- Ⅳ period patients.