Abstract:[Objective] To retrospectively analyze the CT and MRI findings of schwannoma in multiple sites, so as to reduce the misdiagnosis rate of the disease before operation. [Methods] The clinical manifestations and imaging data of 31 cases of schwannoma were collected. Combined with the pathological results, the imaging features of the lesions were analyzed and summarized. [Results]31 cases of schwannomas at different sites were single lesions. The lesions were mainly oval and round(87.10%, 27/31), and a few were dumbbell(9.68%, 3/31) or lobulated (3.23%, 1/31)). Most of the lesions were solid(17/31), followed by cystic with solid(10/31) and cystic(4/31). CT showed slightly low or low density, while MRI showed heterogeneous signal. Enhanced scan showed delayed or continuously enhancement. Most of the lesions(83.87%, 26/31) were along the nerve. Most of the lesions in extremities were cystic with solid, target sign, nerve access and typical fat separation. Cerebrospinal fluid tail sign was found in 11 lesions of the spinal canal(11/12). No typical signs of schwannoma were found in the lesions of the parotid gland, chest wall and gastric wall, which were misdiagnosed before operation. [Conclusion]Schwannoma in common sites have typical imaging features and are easy to diagnose..Schwannoma in rare sites is prone to be misdiagnosed.