Objective:To introduce the surgical technique and preliminary clinical results of the lumbar interbody fusion for treatment of isthmic spondylolisthesis by using the Self-designed intervertebral processors and “Autologous Cage” developed by the autologous spinous, lamina and articular process.Methods:From January 2014 to January 2019,a total of 175 patients with isthmic spondylolisthesis were treated by using the Self-designed intervertebral processor and “Autologous Cage”.During the operation, spinous, lamina and articular process of the diseased segment were completely stripped and removed. The Self-designed intervertebral processor was used to processing the intervertebral disc. And then，autologous spinous, lamina and articular process was trimmed to the appropriate shape bone cage depending to the intervertebral height. After implanting bone, the pre-bent connecting rod of appropriate length were installed and fixed with satisfactory slipped reduction confirmed by C-arm.The Oswestry dysfunction index score (ODI) was used to evaluate the efficacy, and the interbody fusion was evaluated by imaging. Results:All patients were successfully operated. The operation time was (139.24±35.36) min，and the intraoperative blood loss was (275.13±93.22) ml. There was no nerve root injury. To evaluate the effect of interbody fusion and make it clear whether the internal fixation had loosening, prolapse, breakage and other complications, X-ray or CT examinations were performed within 1 week, 3 months, 6 months, 12 months and the last follow-up after operation. At the last follow-up, all patients had satisfactory curative effects with no internal fixation loosening, prolapse, or breakage.Conclusion:Using the Self-designed intervertebral processor and “Autologous Cage”to treat isthmic spondylolisthesis can achieve high bone graft fusion rate,lower incidence of internal fixation complications.