[Objective] To compare the clinical outcomes of Ilizavor fixation versus cannulated compression screws fixation for ankle arthrodesis. [Methods] A retrospective study was done on 61 patients who received ankle arthrodesis for end-stage ankle arthrosis from June 2010 to January 2018. Among them, 35 patients were treated with Ilizavor fixation (the EF group), whereas 26 patients received cannulated compression screws (the IF group). The perioperative, follow-up and radiographic documentations were compared between the two groups. [Results] All the 61 patients had operation performed smoothly. There were no significant differences in operation time and total incision length between the two groups (P＞0.05), whereas the EF group proved significantly superior to the IF group regarding to intraoperative blood loss and hospital stay（P＜0.05）. All the patients were followed up more than 12 months. The VAS score significantly decreased, whereas the AOFAS score significantly increased in both group（P＜0.05）. Regardless no statistical significances before operation and at 12 months after operation（P＞0.05）, the EF group proved superior to the IF group at 3 months in VAS and AOFAS scores（P＜0.05）. In term of radiographic assessment, there were significant differences at 6 months after operation（P＜0.05）, without a statistically significant difference in bone fusion rate at 3 months between the two group（P＞0.05）. [Conclusion] Two fixations are effective procedure to relieve pain and improve function for end-stage ankle arthrosis, by contrast, Ilizavor fixation can provide high fusion rate and achieve good short term clinical consequences.