Abstract：[Objective] To evaluate the efficacy of bridge combined internal fixation system with mixed-rod by point contact fixation for femoral shaft fractures. [Methods] A retrospective study was conducted on 37 patients with humerus shaft fracture who treated by bridging system in our hospital from January 2016 to December 2018.Of them, 18 cases received point-contact fixation with mixed rod, while the other 19 cases had double-rod. The data were compared between the two groups regarding to perioperative, follow-up and radiographic aspects. [Results] All the patients in both groups had operations completed smoothly . The PC-Fix group had significantly shorter operation time, less blood loss and incision length, whereas more X-ray exposure than the BCFS group (P<0.05),regardless of no significant difference in hospital stay between the two groups (p>0.05).The shoulder abduction – adduction and elbow flexion - extension range of motion, ASES score in both groups increased significantly with time (P<0.05). The scores of shoulder abduction – adduction and elbow flexion - extension activity, ASES in the PC-Fix group were superior to those in the BCFS group (P<0.05) at one month after surgery. However no significant differences regarding the range of motion and ASES scores between the two groups were proved at 6 months after surgery and the last follow-up (p>0.05).According to the Matta radiological criteria, the excellent and good rates was 78% in PC-Fix group and 89% in the BCFS group. There was no significant difference between them(p>0.05).The fracture healing time of PC-Fix group was better than BCFS group (P<0.05).The loosening or breaking of fixator wasn’t observed in both groups. [Conclusion ] BCFS with mixed-rod combined with point contact fixation for the treatment of humeral shaft fractures can be less traumatic and tissue blood supply damaged, which is conducive to early healing of fractures and may be used as a new treatment for humeral shaft fractures.