Abstract:[Objective] To investigate the influence of oblique lateral interbody fusion (OLIF) on SF-12 physiological score (PCS) and sagittal complications for adult lumbar degenerative scoliosis (DLS). [Methods] A retrospective study was performed in 112 adult DLS, they were divided into two groups according to the surgical method:51 patients as OLIF group,61 patients as transforaminal lumbar interbody fusion (TLIF) group. The perioperative conditions and the incidence of sagittal complications were compared between the two groups. the SF-12 PCS, visual analog scale (VAS) and Oswestry dysfunction index (ODI) scores were evaluated, the lumbar spine crown and sagittal position imaging parameters were measured. [Results] There was no significant difference in the operation time, and fusion rate between the two groups (P>0.05);the intraoperative bleeding, postoperative hospital stay, fusion device collapse and sagittal complications in the OLIF group were lower than the TLIF group (P<0.05). At 1 week after surgery, the VAS and ODI scores of the OLIF group were lower than the TLIF group, and the SF-12 PCS score was higher than the TLIF group (P<0.05), but there was no statistically significant difference between the two groups at 6 months after surgery (P>0.05). At 1 week and 6 months after surgery, the lumbar spine crown and sagittal imaging parameters of the OLIF group were better than the TLIF group (P<0.05).[Conclusion] OLIF has the advantages of less surgical trauma and faster postoperative recovery, which can reduce sagittal complications and improve the quality of life of patients.