Objective: To assess the efficacy of associating the microfracture technique with platelet-rich plasma (PRP) injections in the treatment of osteoehondral lesions of the talus to promote acceleration of the healing process. Methods: From March 2016 to December 2018, 23 patients with osteoehondral lesions of the talus (13 males and 10 females, aged 28-45 years) were analyzed retrospectively. All of them showed small area osteoehondral lesions of talar cartilage, and the duration of pain was 10-36 months. Treatment of all patients with arthroscopic microfracture combined with PRP intra-articular injection, and injection of PRP into ankle joint three times regularly. Clinical follow-up was performed at 6 and 12 months after treatment. Clinical function was assessed on the basis of the AOFAS Ankle Hindfoot Scale（AOFAS）.Pain was evaluated using a visual analogue scale (VAS). Magnetic resonance imagin(MRI) was used to evaluate the repair effect of osteoehondral lesions of the talus at 12 months postoperatively. Results: 23 patients were followed up effectively.VAS pain score decreased from preoperative (5.34±0.46) to postoperative 6 months (1.34±0.33) and postoperative 12 months (0.39±0.25).The AOFAS score increased from preoperative (64.43±1.87) to postoperative 6 months (83.21±1.46) and postoperative 12 months (96.39±0.71). The difference of preoperative and postoperative scores was statistically significant (P < 0.05).The patient''s magnetic resonance imagin(MRI) showed improved signs of osteoehondral lesions of the talus at 12 months postoperatively. Conclusion: Our results show that arthroscopic microfracture combined with PRP can effectively reduce pain and improve function in the treatment of small area of osteoehondral lesions of the talus.