Objectives: To investigate the clinical and radiological outcome of open-door laminoplasty for the cervical ossification of the ligamentum flavum (OLF). Methods: A retrospective study was performed on 42 cervical OLF patients who had been treated at Department of Orthopaedics, Wuhan Pu’ai Hospital receiving an open-door laminoplasty from July 2013 to June 2018. All of them were treated with C3～7 open-door laminoplasty. The operative time, intraoperative blood loss and radiological outcomes were recorded. Results: All of patient completed surgery smoothly without complications such as neurological injury or cerebrospinal fluid leakage. The operation time was average 123.9±45.5min, and the intraoperaitve blood loss was 355.3±100.4ml. A total of 34 patients felt less numbness in the limbs and improvement of the muscle strength immediately after surgery. The follow-up period ranged from 25 to 82 months with an average of 46.4±21.6 months. The JOA score at final follow-up was improved significantly than that immediately after surgery (P<0.05), which was also improved significantly than pre-operation (P<0.05). The improving rate of JOA was 65.51±20.46%, and the good and excellent results rate was 83%. The VAS score for axial symptoms at final follow-up was significantly less than before surgery and immediately after surgery (P<0.05), however,the latter was significantly more than pre-operation( P<0.05）. Radiographs showed that the curvature index and cervical curvature at final follow-up remained unchanged(P>0.05). The ratios of spinal canal encroachment significantly decreased and the anteroposterior diameter of spinal cord significantly increased at final follow-up（P<0.05）. The expansion of spinal cord was good.Conclusions: The open-door laminoplasty is an effective operation for the treatment of cervical OLF, which can achieve a satisfactory recovery of neurological function. Although axial symptoms of postoperation may occur or worsen, but it can be generally relieved after a period of recovery and functional exercise.