Abstract Objective To observe the clinical effect of Kirschner wire combined with Nice junction in the treatment of acute acromioclavicular joint dislocation. Methods From April 2017 to April 2020, 59 patients with Rockwood Ⅲ-Ⅴ acute acromioclavicular joint dislocation were selected in our hospital . 24 cases in the observation group were treated with Kirschner wire combined with Nice knots, and 35 cases in the control group were treated with the clavicular hook plate. The operation time, hospitalization time, hospitalization expenses, Visual Analogue Scale, Constant-Murley score, acromioclavicular joint distance and coracoclavicular distance were compared between the two groups. Results ① The operation time and hospitalization expenses of the observation group were significantly lower than those of the control group (P < 0.001). But there was no significant difference in hospitalization time between the two groups (P > 0.05).② All patients were followed up for 8-12 months (mean 10.24 ± 1.86 months). In the observation group, 3 patients had nail tract infection and healed after the Kirschner wire was removed.③ The excellent and good rate of the observation group was 95.83% (21 / 24) and that of the control group was 88.57% (31 / 35) (x2 = 0.015, P = 0.901).④ 6 months after operation, the VAS score of the observation group was significantly lower than that of the control group (P < 0.001). The score of shoulder range of motion in the observation group was significantly better than that in the control group (P < 0.05).⑤ 6 months after operation, the acromioclavicular joint distance and the coracoclavicular distance of the observation had no significant difference (P > 0.05). Conclusion Kirschner wire combined with nice knot fixation in the treatment of Rockwood type Ⅲ-Ⅴ acute acromioclavicular joint dislocation could restore the shoulder joint function, is a simple and practical surgical scheme.