Objective Discuss short-term efficacy of early assessment and treatment of Knee Dislocation with Multiple Ligament Injuries. Methods From March 2015 to December 2017,Early assessment and treatment for 24 knee dislocations with multiple ligament injuries after hospitalization. Patients with knee dislocation were restored,and emergency open reduction and fixation, if the knee dislocation was unable to manual their evaluation. The merger ligament injuries were repaired or reconstructed in one-stage. Patients with vascular and nerve injury were explored or reconstructed and combined ligament injury were repaired and/or reconstructed for one-stage. Results All patients completed the knee X-ray, MRI and intravenous color ultrasound examination, and completed the CTA examination if necessary, to assess the knee ligament and blood vessel damage before operation. The tibial displacement on stress was (12.67±1.95) mm, and The external rotation angle of tibia at 30° knee flexion (Dial-test) was (11.25±3.40)°, the Lysholm score of the knee joint was (35.50±5.66), and the International Knee Documentation Committee (the?international?knee?documentation?committee, IKDC) scored 24 cases before surgery all were D grade.All patients were fellowed range from 12 to 19 months. Surgical incisions are uniformly healed without complications such as blood vessel and nerve damage. The postoperative knee X-ray at the last follow-up showed that the joint alignment was well. The tibial displacement on stress was (2.92±1.35) mm, the external rotation angle of tibia at 30° knee was (1.58±2.24)°, the Lysholm score was (35.50±5.66), and the subjective score of the IKDC scored 9 cases in grade A and 15 cases in grade B.The difference in tibia posterior shift distance, knee flexion 30° Dial-test, Lysholm score and preoperative comparison were statistically significant (P<0.05).Conclusion It’s important that the early assessment and treatment option was formulated for knee dislocation with multiple ligament injuries, which can obtain good short-term effectiveness.