Objective: To investigate the clinical effect of percutaneous minimally invasive bridge combined fixation system (BCFS) and reconstruction plate in the treatment of clavicle fractures. Methods: A retrospective study of 57 patients with clavicle fractures admitted to the Department of Orthopedics of our hospital from January 2015 to July 2019 were divided into control group (n=27, using reconstruction plate internal fixation) and observation group ( n=30, using BCFS). The perioperative condition, postoperative curative effect and shoulder joint function of the two groups were compared. Results: The operation time, incision length, intraoperative blood loss and fracture healing time of the observation group were significantly better than those of the control group (P<0.05); the complication rate of the control group (14.81%) was significantly higher than that of the observation group (3.33%) (P <0.05); At the last follow-up, the efficacy scores, Constant-Murley scores of shoulder joints and Neer scores of the two groups were improved compared with preoperatively, and the scores of the observation group were significantly better than those of the control group (P<0.05). Conclusion: As a new internal fixation method for the treatment of clavicle fractures, BCFS has the advantages of quick postoperative recovery, fewer complications, and good recovery of shoulder joint function. At the same time, it can reduce the risk of internal fixation fracture and is worthy of clinical promotion.