[Abstract]Objective:To explore the effect of meta intramedullary nail and common intramedullary nail in the treatment of tibial fracture and its influence on the function and prognosis of knee joint.Methods:From January 2012 to December 2018, 80 patients with tibial fracture admitted to the hospital were selected as the study objects. The simple random number table method was divided into treatment group and control group, with 40 cases in each group. Patients in the treatment group were treated with meta intramedullary nail through the patellar approach, while patients in the control group were treated with common intramedullary nail through the patellar approach. After 12 months follow-up, the clinical effect, knee joint function score (HSS) and complications of the two groups were compared.Results:Comparison of HSS scores before and after surgery in the two groups was statistically significant (P<0.05); there was no significant difference in HSS scores between the two groups before, 1 and 3 months after surgery (P>0.05), and the difference was statistically significant at 6 and 12 months after operation (P<0.05). The clinical efficacy of the two groups was statistically significant (P<0.05). The total effective rate of clinical efficacy in the treatment group was 87.50%, which was better than 67.50% in the control group. The difference was statistically significant (P<0.05). There was no significant difference in the complications between the two groups (P>0.05). The incidence of complications in the treatment group was 7.50%, which was lower than the 25.00% in the control group. The difference was statistically significant (P<0.05).Conclusions:Meta intramedullary nail patellar approach can obtain better curative effect and prognosis than common intramedullary nail patellar approach in the treatment of tibial fractures, and the improvement of knee joint function is higher, which is worthy of clinical promotion.