Abstract Objective To observe the effect of KinesioTaping on limb swelling and joint function after total knee arthroplasty, so as to provide help for patients with rapid rehabilitation. Methods: From January 2018 to June 2019, 127 patients with total knee arthroplasty were randomly divided into KinesioTaping group (63 cases) and control group (64 cases). The Visual Analogue Scale(VAS), limb swelling, quadriceps muscle strength, knee joint range of motion(ROM) and knee joint function score (HSS) were observed at 3 days, 14 days and 30 days after operation. Results ① All patients were followed up for 3-6 months (mean 4.821.04 months). In the KinesioTaping group, 3 patients had skin reaction in the ligation area, and 1 patient withdrew from the observation. and 5 patients with lower extremity intermuscular venous thrombosis. In the control group, 7 patients developed intramuscular venous thrombosis.② There was no difference in VAS score, limb swelling degree, quadriceps muscle strength, ROM and HSS score between the two groups 3 days after operation (P > 0.05), and gradually improved with the extension of postoperative recovery time. ③ At 14 days after operation, the VAS score of KinesioTaping group was significantly lower than that of control group (P < 0.01). 14 days and 30 days after operation, the swelling degree in the KinesioTaping group was significantly better than that in the control group (P < 0.05). ④ 14 days and 30 days after operation, ROM and HSS scores in KinesioTaping group were significantly better than those in control group (P < 0.001). Conclusion The KinesioTaping could significantly relieve limb swelling, improve quadriceps muscle strength and joint function after total knee arthroplasty.