Abstract: [Objective] To investigate the influence of double-incision locking plate internal fixation combined with different bone repair materials bone graft on fracture healing and imaging collapse for patients with complex tibial plateau fractures. [Methods] The clinical data of 92 patients with tibial plateau fractures who underwent double-incision locking plate internal fixation were retrospectively analyzed. Among them,31 cases (group A) were treated with autologous iliac bone graft,34 cases (group B) were treated with allograft bone graft,27 cases (group C) were treated with bionic artificial bone graft. The operation-related conditions, postoperative complications, and fracture healing of the three groups and imaging collapse were compared. The tibial plateau varus angle (TPA) and medial posterior tilt angle (PA) were measured, the Rasmussen knee fracture reduction anatomy score and Hospital for Special Surgery (HSS) score were evaluated. [Results] The intraoperative blood loss and operation time in group A were higher than those in groups B and C (P<0.05), but there was no statistically significant difference between groups B and C (P>0.05);the postoperative drainage volume of the three groups was not statistically significant (P>0.05).During 12 months of follow-up, in term of Hospital for Special Surgery (HSS) standard, the excellent and good rates of group A, group B, and group C were 80.65%, 76.47%, and 85.19%, respectively. There was no statistically significant difference between the three groups (P>0.05). The main complication of group A was pain and discomfort in the donor area (19.35%), group B was mainly wound exudate (14.71%) and rejection (11.76%), and group C had only 1 case of wound exudate. There was no statistically significant difference in fracture healing time, tibial plateau varus angle (TPA) and medial posterior tilt angle (PA) and Rasmussen scores among the three groups (P>0.05). The rates of articular surface collapse in groups A, B, and C were 12.90%, 14.71%, and 3.70%, respectively. There was no statistically significant difference between the three groups (P>0.05). [Conclusion] For complex tibial plateau fractures, double-incision locking plate internal fixation combined with different bone repair materials bone graft do achieve good clinical outcomes. Bionic artificial bone is fine surrogate of transplantation materials with good bone conductivity and inducibility and no immune rejection.