Abstract: [Objective] The Zweymüller bioprosthetic long-handle revision treatment is used in patients with Vancouver B3 perifemoral fractures (PFF) after hip replacement (THA) and compared with traditional bone cement prostheses to analyze their safety Sex and effectiveness. [Methods] A retrospective analysis of 176 patients with PFF admitted to our hospital from June 2017 to December 2019, patients in the biological group received revision of the Zweymüller bioprosthetic femoral prosthesis (92 cases), and the bone cement group received bone cement type long Revision of shank femoral prosthesis (84 cases). [Results] The operation time, intraoperative blood loss, hospitalization time and fracture healing time of patients in the biological group were significantly lower than those in the bone cement group (P<0.05). At the last follow-up, the hip pain and function scores of the two groups of patients were significantly improved, and the pain and function scores of the biological group were significantly better than the bone cement group (P<0.05); the incidence of adverse reactions in the biological group was significantly lower In the bone cement group (P<0.05); the imaging indicators of the femoral neck anteversion angle, neck shaft angle, and femoral shaft anterior arch angle of the two groups of patients were significantly improved, and the improvement in the biological group was significantly better than the bone cement group (P <0.05). [Conclusion] The use of Zweymüller long-handle revision treatment in Vancouver B3 PFF patients has the advantages of safety, high efficiency and low invasive application. It is satisfactory in improving fracture treatment, restoring hip function and relieving pain symptoms; Reduce the incidence of adverse events.