Abstract:[Objective] To explore the effect of dexamethasone combined with celecoxib on pain degree and bone metabolism indexes of knee osteoarthritis patients. [Methods] 88 patients with knee osteoarthritis who were treated in our hospital from January 2019 to November 2019 were randomly divided into control group and research group with 44 cases in each group. The control group was treated with dexamethasone, while the research group was treated with dexamethasone combined with celecoxib. The clinical effects, the changes of osteoarthritis index, international osteoarthritis (Lequesne) score, pain factor, visual analogue pain score (VAS) and bone metabolism index of western ontario and mcmaster university (WOMAC) before and after treatment of the two groups were compared. [Results] After treatment, the total effective rate of the research group was higher than that of the control group (P<0.05). After treatment, WOMAC score and Lequesne score of the two groups decreased compared with those before treatment, and the research group was lower than the control group (P<0.05). The pain factors and VAS scores of the two groups were lower than those before treatment. the above indexes in the study group were lower than those in the control group, there was a statistical difference (P<0.05). The bone metabolism indexes of the two groups were higher than before treatment, and the research group was higher than the control group (P<0.05). [Conclusion] Dexamethasone combined with celecoxib is an effective method for the treatment of knee osteoarthritis, which can relieve knee joint pain, regulate bone metabolism and promote the recovery of knee joint function.