Abstract:[Objective]To evaluate the risk factors related to periprosthetic joint infection after total knee arthroplasty.[Methods] A comprehensive Meta-analysis of the clinical research from January 2014 to November 2019 published athome and abroad was conducted after CNKI,Wanfang Data,PubMed,et al,had been searched.The Revman 5.3 software was used to perform a meta-analysis after a strict quality assessment of the retrieved data.[Results] A total of 11 papers were included for the meta-analysis involving 10791 patients of whom 419 occur PJI after total knee arthroplasty.The factors related to PJI after total knee arthroplasty included patient age [OR=2.80,95%CI(1.91,4.10),P<0.05],Combined diabetes[OR=2.90,95%CI(1.81,4.64),P<0.05],Operation time[OR=2.63,95%CI(1.90,3.65),P<0.05],Smoking[OR=2.60,95%CI(1.54,4.39),P<0.05],Combined Inflammatory disease(Rheumatoid Arthritis)[OR=12.56,95%CI(5.08,31.01),P<0.05],Hormone use[OR=6.066,95%CI(1.788,20.63),P<0.05],Postoperative drainage tube removal time[OR=4.23,95%CI(2.29,7.80),P<0.05],Obesity[OR=1.40,95%CI(1.08,3.87),P<0.05],and it has no connection?with?anemia[OR=4.48,95%CI(0.69,29.23),P>0.05].[Co-nclusions] High age,Combined diabetes,Long Operation time,Smoking,Combined Inflammatory disease(Rheumatoid Arthritis),Hormone use,Postoperative drainage?tube?removal?time(≥24h),Obesity m-ay be the risk factors closely related to PJI after total knee arthroplasty.