【Abstract】Objective This study aims to compare and analyze the intraoperative and postoperative differences between the anterior median patellar incision and the traditional medial incision in single condyle replacement. Methods A total of 72 patients with single condyle joint replacement admitted to Beijing tsinghua changgeng hospital were retrospectively selected. According to the different incision methods, they were divided into experimental group and control group. The experimental group adopted anterior median patellar incision, and the control group adopted medial incision.Albumin and hemoglobin were measured in all patients before and on day 1, 3 and 5 after surgery. Results There was no significant difference in albumin and hemoglobin values between the experimental group and the control group (P > 0.05).The measurements of albumin and hemoglobin on day 1, 3, and 5 after surgery were significantly different from those before surgery (P < 0.05). The change of Alb on the fifth day after the operation was statistically significant between the two groups (P < 0.05), and the other differences were not statistically significant. Both Alb and Hb reached the lowest value on the 3rd day after operation.Conclusion The median incision can achieve the same clinical effect as the traditional medial incision, but it has advantages in preventing surgical complications and temporarily changing the surgical method.