Abstract Objective: Objective: To observe the feasibility and clinical effect of percutaneous pedicle approach for the treatment of free prolapsed lumbar disc herniation. Methods: From June 2019 to January 2020, our department treated 32 patients with free prolapsed lumbar intervertebral disc herniation, all of which had varying degrees of low back pain with numbness of the lower extremities and superficial skin sensation symptoms; of which 18 were male and 14 female For example, the age is 60±4.3 years old (43-72 years old). The patient underwent percutaneous pedicle approach for intervertebral foramen underwent lumbar discectomy under intravenous general anesthesia. Record the operation time, postoperative complications, VAS and ODI scores of each patient before and after surgery; evaluate the sensory and motor status of the limbs after surgery by lumbar spine CT, MRI, and three-dimensional CT. Results: All patients had a smooth operation, no nerves, blood vessels and dura mater were damaged during the operation, no pedicle fractures were found during or after the operation, and there was no abnormal sensory and movement of the limbs after the operation. The average operation time was 96.52±13.16 minutes during the operation; the patients were relieved with postoperative low back and leg pain, with an average follow-up of 4.7±1.4 months (from March to June), 1 day and 1, 3, and 6 months postoperative VAS and ODI scores It was significantly lower than before operation (P<0.01), and the difference was statistically significant (P<0.05). Conclusion: Percutaneous pedicle approach for intervertebral foramen underwent free prolapsed lumbar disc herniation with satisfactory postoperative results and good clinical prognosis.