ObjectiveTo studyCurative efficacy ofInternal fixation combined with vertebroplastyin treatment ofSpinal fracturesand its effectsonTumor necrosis factor (TNF-α), interleukin 6 (IL-6).Methods100 patients with spinal fractures who were treated in our hospital from June 2017 to June 2019 were selected and divided into observation group (n=52) and control group (n=48) by lottery. The control group was treated with traditional internal fixation, and the observation group was treated with internal fixation combined with vertebroplasty. The operative status, TNF-, il-6, the high compression rate of the anterior edge of the vertebral body, the high compression rate of the posterior edge of the vertebral body, the injured vertebra height, the change of Cobb Angle level and the occurrence of complications were compared between the two groups.ResultsThe operative time of the observation group was significantly higher than that of the control group, and the intraoperative blood loss and hospitalization time were significantly lower than that of the control group, with significant differences (P<0.05). Before treatment, there was no significant difference in TNF- and il-6 levels between the two groups. After treatment, the levels of TNF- and il-6 in both groups were significantly reduced, and the difference was significantly lower in the observation group than in the control group (P<0.05). Before treatment, there was no significant difference between the two groups in the level of vertebral compression. After treatment, the high compression rate of the anterior edge of the vertebral body and the high compression rate of the posterior edge of the vertebral body in the two groups decreased significantly, and the difference was significantly lower in the observation group than in the control group (P<0.05). Before treatment, there was no significant difference in the level of vertebral height and Cobb Angle between the two groups. After treatment, the level of injured vertebral height was significantly increased in both groups, and the Cobb Angle was significantly increased in both groups. Moreover, the injured vertebral height in the observation group was higher than that in the control group, and the Cobb Angle was lower than that in the control group, with significant differences (P<0.05). The total incidence of complications in the two groups was 1.92% and 18.75%, respectively, with statistically significant differences (P<0.05).conclusionThe application of internal fixation combined with vertebroplasty in patients with spinal fractures has a significant effect, which can effectively reduce spinal injury in patients with fewer complications.