全髋关节置换术后异位骨化形成的危险因素及预防措施的研究进展
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天津市天津医院

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Research progress on the risk factors and preventive measures of Heterotopic ossification after total hip arthroplasty
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Tianjin Hospital

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    摘要:

    异位骨化(Heterotopic ossification,HO)是指在正常骨组织以外的组织中出现骨形成。HO是全髋关节置换术常见的并发症。目前被认为是危险因素包括髋部强直、男性、既往HO史。最常用的是采用Brooker分类将HO分为四个等级的。最有效的预防措施是放疗或服用NSAIDs。放疗方案是术后一次性给予7戈瑞。预防HO最常用的非甾体药物是消炎痛,布洛芬的疗效也得到了证实。选择性COX-2抑制剂预防HO效果显著,且副作用更小。症状性HO的治疗方法是手术切除HO或翻修性关节成形术。本文总结有关全髋关节置换术后异位骨化的影响因素及预防措施的研究进展。

    Abstract:

    Heterotopic ossification (HO) refers to bone formation in tissues other than normal bone tissue.HO is a common complication of total hip arthroplasty(THA). Current risk factors for HO formation include hip stiffness, male sex, and previous HO history.Most commonly, HO would be divided into four grades using the Brooker classification.The most effective preventive measures are radiation therapy or oral nonsteroidal anti-inflammatory drugs.The radiotherapy regimen is a postoperative one-time dose of 7 Gy.The most commonly used nonsteroidal drug to prevent HO is indomethacin, and ibuprofen has been shown to be effective.Selective cox-2 inhibitors are effective in preventing HO with less side effects.Symptomatic HO is treated with surgical excision or revision arthroplasty.This article would summarize the research progress on the influencing factors and preventive measures of HO after total hip arthroplasty.

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历史
  • 收稿日期:2020-04-30
  • 最后修改日期:2020-04-30
  • 录用日期:2020-07-23
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