[Abstract] [Objective] To explore the clinical effect of plate and screw internal fixation for the treatment of traumatic fractures of long tubular bones of extremities. [Method] Twenty patients with long tubular bone fractures of extremities who were admitted to our hospital from November 2017 to November 2019 were selected. According to different fixation methods, they were divided into steel plate screw group and interlocking intramedullary nail group, 10 cases in each group. The interlocking intramedullary nail group was treated with interlocking intramedullary nail fixation, and the plate and screw group was treated with plate screw internal fixation. The perioperative indicators and clinical efficacy of the two groups of patients were compared. [Results] Both groups of patients successfully completed the operation. The perioperative indicators of the patients in the plate and screw group were significantly better than those in the interlocking intramedullary nail group, the difference was statistically significant (P <0.05); In the interlocking intramedullary nail group, the difference was statistically significant (P <0.05); the plate and screw group had a lower complication rate than the interlocking intramedullary nail group, and the difference was statistically significant (P <0.05). [Conclusion] Internal fixation with plate and screw for the treatment of traumatic fractures of long tubular bones in extremities can effectively promote the improvement of patients'' joint function and is worthy of clinical application.