[Abstract]：Objective: The objective of this study was to describe a novel percutaneous transforaminal endoscopic decompression (PTED) for degenerative lumbar spondylolisthesis (DLS) in the elderly and demonstrate the clinical outcomes. Methods: From January 2017 to January 2019, 26 consecutive patients aged 60 and older were diagnosed LDS in our institution and underwent PTED. All cases were followed up to 1 years postoperatively. The visual analogue scale (VAS) and Oswestry Disability Index (ODI) were evaluated before and 3, 6 and 12 months after surgery. The clinical outcomes were evaluated using modified MacNab criteria after surgery. Results :The mean time in the operating room was 66.5±16.0 minutes. The mean±SD value of preoperative VAS leg pain score was 7.3±1.2 , the score improved to 2.3±1.2 at 12 months postoperatively (P < 0.01). The mean±SD value of the preoperative ODI score was (65.7±9.8)%, the scores improved to(21.6±8.6)% at 12 months postoperatively (P < 0.01). The outcomes of the modified MacNab criteria showed that 84.6% of patients obtained good-to-excellent rate . The percent slip of spondylolisthesis before surgery (13.9±2.2)% and at the end of follow-up (14.1±2.2)% was not statistically significant different. Conclusion: PTED under local anesthesia may be an effective treatment method for DLS with unilateral radiculopathy elderly patients.