Objective:By comparing the impact of the timing of drainage tube extraction after total knee arthroplasty on patients' early clinical effects, the optimal timing of tube extraction after total knee arthroplasty was explored.Methods: A total of 110 patients who underwent unilateral total knee arthroplasty from February to May 2019 in the Department of Joint Surgery, Affiliated Hospital of Qingdao University were randomly divided into a 24h postoperative extubation group and a 48h postoperative extubation group, with 55 patients in each group , record the clinical Visual Analogue Score (VAS), leg circumference, range of mobility (ROM), hemoglobin and infection-related biochemical indicators, knee function score (KSS), wound healing, etc. of each patient before and after surgery data.Results：All patients in the two groups were followed up for statistical analysis: postoperative drainage volume was significantly lower in the 24h group than that in the 48h group and the difference was statistically significant (P<0.05). The peripheral diameter and KSS score of the two groups were significantly improved compared with those before surgery, but the difference was not statistically significant (P>0.05). VAS score and ROM score on the second day after surgery were significantly better in the 24h group than those in the 48h group (P<0.05). There was no statistically significant difference between the two groups in the results of preoperative and postoperative infection-related biochemical indexes (P>0.05).Conclusion:The early clinical effect of extubation 24h after operation was better than that of 48h after operation, which was the appropriate time for extubation.